Combinations of four or more CpGs methylation present equivalent predictive value for MGMT expression and temozolomide therapeutic prognosis in gliomas.

CONCLUSIONS: Four-CpG combinations of pyrosequencing are sufficient for evaluating the methylation status of MGMT and predicting therapeutic prognosis in gliomas. PMID: 30117294 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30117294?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - August 16, 2018 Category: Neuroscience Authors: Chai RC, Zhang KN, Liu YQ, Wu F, Zhao Z, Wang KY, Jiang T, Wang YZ Tags: CNS Neurosci Ther Source Type: research