Pathogenesis of hepatic encephalopathy in chronic liver disease

Publication date: Available online 18 August 2018Source: Journal of Clinical and Experimental HepatologyAuthor(s): Rafael Ochoa-Sanchez, Christopher F. RoseAbstractHepatic encephalopathy (HE) is a complex neuropsychiatric syndrome that occur during chronic liver disease (CLD). While ammonia and other precipitating factors in liver disease including inflammation, bile acids, oxidative stress and lactate play a role in the pathogenesis of HE, the exact mechanism that leads to HE is not fully understood. Notably, accumulating evidence points towards a synergic effect rather than independent actions between precipitating factors that contributes to the development and severity of HE in CLD. Hence, this review is aimed to briefly discuss the single and synergic interplay of pathological factors in the progression and severity of HE.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research