Carbamate-bearing surfactants: Micellization, solubilization, and biological activity

Publication date: 1 November 2018Source: Journal of Molecular Liquids, Volume 269Author(s): Alla B. Mirgorodskaya, Rushana A. Kushnazarova, Svetlana S. Lukashenko, Alexandra D. Voloshina, Oxana A. Lenina, Lucia Ya. Zakharova, Oleg G. SinyashinAbstractHerein novel cationic carbamate-bearing surfactants have been synthesized and characterized as effective building blocks for the development of polyfunctional nanosystems showing solubilizing, antimicrobial and membrane-tropic activity. For this purpose aggregation behavior of the surfactants has been evaluated, with the structure of head group and hydrophobicity varied. Their concentration and temperature ranges of micelle formation have been determined through tensiometry and conductometry: critical micelle concentration, Krafft point and adsorption parameters at the interface have been quantified. Solubilization of hydrophobic probes (Orange OT and pyrene) has been employed to determine aggregation numbers, evaluate solubilization capacity of micelles, and characterize micropolarity in the localization site of the probe. The value of LD50 of the carbamate-bearing surfactants has been determined (mice, intraperitoneal administration). It has been shown that the surfactants can be related to the class of moderately toxic compounds. Investigation of antimicrobial properties of carbamate-bearing surfactants has determined their significant antibacterial and antifungal activity against Staphylococcus aureus, Escherichia coli, Bacil...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research