Regulatory T cells in ovarian cancer are characterized by a highly activated phenotype distinct from that in melanoma.

CONCLUSIONS: The highly activated phenotype of ovarian tumor-infiltrating Treg cells may be a key component of an immunosuppressive tumor microenvironment. Receptors that are expressed by tumor-infiltrating Treg cells could be exploited for the design of novel combination tumor immunotherapies.
PMID: 30065096 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - July 31, 2018 Category: Cancer & Oncology Authors: Toker A, Nguyen LT, Stone SC, Yang C, Katz SR, Shaw PA, Clarke BA, Ghazarian DA, Al Habeeb AS, Easson AM, Leong W, McCready D, Reedijk M, Guidos CJ, Pugh TJ, Bernardini MQ, Ohashi PS Tags: Clin Cancer Res Source Type: research