A simulation approach for determining the spectrum of DNA damage induced by protons.

A simulation approach for determining the spectrum of DNA damage induced by protons. Phys Med Biol. 2018 Aug 03;: Authors: Mokari M, Alamatsaz MH, Moeini H, Taleei R Abstract In order to study the molecular damage induced in the form of single-strand and double-strand breaks by the ionizing radiation at the DNA level, Geant4-DNA Monte Carlo simulation code for complete transportation of primary protons and other secondary particles in liquid water have been employed in this work. To this aim, a B-DNA model and a thorough classification of DNA damage concerning their complexity were used. Strand breaks were assumed to have been primarily originated by direct physical interactions via energy depositions, assuming a threshold energy of 17.5 eV, or indirect chemical reactions of hydroxyl radicals, assuming a probability of 0.13. The simulation results on the complexity and frequency of various damage are computed for proton energies of 0.5 to 20 MeV. The yield results for a cell (Gy.cell)-1 are presented, assuming 22 chromosomes per cell and a mean number of 245 Mbp per chromosome. The results show that for proton energies below 2 MeV, more than 50% of energy depositions within the DNA volume resulted in strand breaks. For double-strand breaks (DSBs), there is considerable sensitivity of DSB frequency to the proton energy. A comparison of DSB frequencies predicted by different simulations and experiments is presented as a function of pro...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research