Correction of Anemia in Chronic Kidney Disease With Angelica sinensis Polysaccharide via Restoring EPO Production and Improving Iron Availability

Kaiping Wang, Jun Wu, Jingya Xu, Saisai Gu, Qiang Li, Peng Cao, Mingming Li, Yu Zhang, Fang Zeng
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research

Related Links:

Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Hemoglobin concentration (g/L; black circles), deviation (%) from idealized plasma volume (PV (%); white bars) and deviation (%) from idealized red blood cell volume (RBCV (%); grey bars) in non ‐anemic (left from vertical dotted line) and anemic (right from vertical dotted line) CKD male patients. This figure illustrates the fact that most patients with anemia in predialysis CKD have an increase in plasma volume and a relatively normal RBCV, supporting the fact that anemia of CKD may oft en be dilutional. AbstractAnemia is defined according to decreased blood hemoglobin concentration ([Hb]), which is considered a marker...
Source: Physiological Reports - Category: Physiology Authors: Tags: Original Research Source Type: research
The objective of the study was to examine overall anemia management trends in non-dialysis patients with chronic kidney disease (CKD) from 2006 to 2015, and to evaluate the impact of Trial to Reduced Cardiovas...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
Conclusion: L-carnitine supplementation increased calcium and phosphate plasma concentrations with no detected downregulation effect on PTH and FGF23. (Clinical Trial 00322322, May 5, 2006).Am J Nephrol 2018;48:349 –356
Source: American Journal of Nephrology - Category: Neurology Source Type: research
AbstractThe serum levels of hepcidin generally increase in patients with chronic kidney disease (CKD) due to inflammation or a decline in the glomerular filtration rate. However, the differences in the ferrokinetics among dialysis modalities are unclear. We investigated the relationship between serum levels of hepcidin and ferritin among non ‐dialyzed CKD (ND), hemodialysis (HD), and peritoneal dialysis (PD) patients. We recruited 285 CKD patients (117 ND, 80 HD, and 88 PD patients) and measured the serum levels of hepcidin‐25, ferritin, hemoglobin, iron, transferrin saturation (TSAT), albumin, and high sensitivity C...
Source: Therapeutic Apheresis and Dialysis - Category: Hematology Authors: Tags: Original Article Source Type: research
te; D Abstract BACKGROUND: The use of L-carnitine has been proposed in haemodialysis (HD) when deficiency is present to improve anaemia resistant to erythropoietin stimulating agent, intradialytic hypotension or cardiac failure. We tested the effects of L-carnitine supplementation on parameters of chronic kidney disease-mineral bone disorder. METHODS: CARNIDIAL was a randomized, double-blinded trial having included 92 incident HD subjects for a 1-year period to receive L-carnitine versus placebo. Determinant factors of C-terminal fibroblast growth factor 23 (cFGF23) and intact FGF23 were studied including Klo...
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: Am J Nephrol Source Type: research
ConclusionEPO could promote VSMCs calcificationin vitro andin vivo and this effect may be achieved through the JAK2/STAT3/BMP-2 axis and NF- κB pathway.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Understanding the physiology of the kidney and the pathophysiology of common complications of chronic kidney disease (CKD) is essential. The rise of CKD across the United States demands that nurses be prepared to care for these patients. Cardiovascular complications, anemia, and bone formation issues are the most common complications. Approximately 30 million people (15% of adults) are reported to have CKD. By 2020 there will be a 14.4% increase in the prevalence of CKD, and by 2030, the increase will be up by 16.7%. Nurses are integral to providing care that can slow or halt the progression of CKD.
Source: Nursing Clinics of North America - Category: Nursing Authors: Source Type: research
Authors: Orozco-González CN, Cortés-Sanabria L, Márquez-Herrera RM, Núñez-Murillo GK Abstract Pica is an individual entity in the patient with chronic kidney disease (CKD), which phenomenon has not been widely studied despite the high reported prevalence. Moreover, pica complications (anemia, altered electrolytes, poor absorption of micro and macronutrients and malnutrition) could be exacerbated in CKD and limit the quality of renal replacement therapy. The intake of non-caloric and non-nutritional substances could be harmful and cause effects on satiety and metabolic / electrolyt...
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
ConclusionsRecurrent AKI is a common occurrence after a hospitalization complicated by AKI. Based on routinely available patient characteristics, our findings could facilitate identification of the subgroup of patients with AKI who may benefit from more intensive follow-up to potentially avoid recurrent AKI episodes.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
More News: Anemia | Chronic Kidney Disease | Dong Quai | Drugs & Pharmacology | Iron | Urology & Nephrology