Tolerability of prosthetic joint infection empirical antimicrobial therapy: a prospective cohort study.

Conclusions: The EAT of PJI is associated with an important rate of AE, linked with the use of the vancomycin and piperacillin/tazobactam combination. These results corroborate recent finding suggesting a synergic toxicity of these drugs in comparison with vancomycin-cefepime, which remain to be evaluated in PJI.
PMID: 30038037 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - July 23, 2018 Category: Microbiology Authors: Triffault-Fillit C, Valour F, Guillo R, Tod M, Goutelle S, Lustig S, Fessy MH, Chidiac C, Ferry T, Lyon BJI study group Tags: Antimicrob Agents Chemother Source Type: research