in vitro Activity of Oritavancin in Combination with Rifampin or Gentamicin Against Prosthetic Joint Infection-Associated Methicillin-Resistant Staphylococcus epidermidis Biofilms

Staphylococci are the most frequent bacteria associated with prosthetic joint infections (PJIs) [1]. Among them, Staphylococcus aureus and Staphylococcus epidermidis represent the two most common species [1,2]. PJIs pose a significant economic burden to both affected patients and the healthcare system [3]. Staphylococci can attach to surfaces and form dense, multilayered biofilms, surrounded by an extracellular polymeric matrix, which aids in conferring biofilm structure, while also providing protection from environmental stresses [4].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research