Lidocaine and Pinacidil Added to Blood

Objective: The present study aimed the functional recovery evaluation after long term of
cardiac arrest induced by Custodiol (crystalloid-based)
versus del Nido (blood-based) solutions, both added
lidocaine and pinacidil as cardioplegic agents. Experiments were performed
in isolated rat heart perfusion models.Methods: Male rat heart perfusions, according to Langendorff technique, were induced
to cause 3 hours of cardiac arrest with a single dose. The hearts were
assigned to one of the following three groups: (I) control; (II)
Custodiol-LP; and (III) del Nido-LP. They were evaluated after ischemia
throughout 90 minutes ...

Source: Brazilian Journal of Cardiovascular Surgery - July 20, 2018 Category: Cardiology Source Type: research