Obesity and inflammation -- A deadly combination for prostate cancer

(Osaka University) A new Osaka-centered study identified the mechanisms of high-fat diet (HFD)-induced prostate cancer progression. They observed in a mouse model that HFD accelerated tumor growth and increased the myeloid-derived suppressor cells fraction and M2/M1 macrophage ratio. Additionally, the anti-inflammatory drug celecoxib suppressed tumor growth. Their results suggest that HFD-induced prostate cancer growth via cytokine IL6 signaling could also exist in obese humans, and celecoxib may have clinical benefits for obese patients with prostate cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news