Cardiorenal complications of immune checkpoint inhibitors

Cardiorenal complications of immune checkpoint inhibitorsCardiorenal complications of immune checkpoint inhibitors, Published online: 16 July 2018; doi:10.1038/s41581-018-0035-1Immune checkpoint inhibitors (ICIs) have led to a paradigm shift in cancer therapy; however, these agents can induce immune-related adverse events (irAEs) in off-target organs. This Review describes the mechanism of action of ICI therapies and how these agents induce irAEs in the kidney and heart.

http://feeds.nature.com/~r/nrneph/rss/current/~3/-Vow-wepo7Y/s41581-018-0035-1

Source: Nature Reviews Nephrology - July 16, 2018 Category: Urology & Nephrology Authors: Krishna Sury Mark A. Perazella Anushree C. Shirali Source Type: research