No association of salivary total tau concentration with Alzheimer's disease.

In this study, we quantified salivary total tau (t-tau) concentration in 160 healthy elderly control, 68 mild cognitive impairment, and 53 AD participants using ultrasensitive Single molecule array (Simoa) technology. No median difference in salivary t-tau concentration was found between AD and mild cognitive impairment or healthy elderly control (12.3 ng/L, 9.8 ng/L and 9.6 ng/L, respectively, p = 0.219). In addition, there was no association of salivary t-tau concentration with neurophysiological assessment or structural magnetic resonance imaging. Despite a nominal increase in AD, due to the large overlaps in concentrations between clinical groups, we conclude that salivary t-tau is a suitable biomarker neither for AD nor for cognitive impairment. PMID: 30007161 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30007161?dopt=Abstract

Source: Neurobiology of Aging - June 20, 2018 Category: Geriatrics Authors: Ashton NJ, Ide M, Schöll M, Blennow K, Lovestone S, Hye A, Zetterberg H Tags: Neurobiol Aging Source Type: research