CME Part I Psoriasis: Which Therapy for Which Patient Psoriasis comorbidities and preferred systemic agents

Psoriasis is a systemic inflammatory disease associated with increased risk of comorbidities such as psoriatic arthritis, Crohn disease, malignancy, obesity and cardiovascular diseases. All these factors have a significant impact on the decision to use one therapy over another. The past decade has seen a paradigm shift in our understanding of the pathogenesis of psoriasis which has led to identification of new therapeutic targets. Several new drugs have gained FDA approval, expanding the psoriasis armamentarium but still a large number of patients continue to be untreated or undertreated.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research

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Authors: Gougelet A Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second cause of cancer-related death worldwide. The incidence of HCC is constantly increasing in correlation with the rise in diabetes and obesity, arguing for an urgent need for new developments in the treatment of this lethal cancer. Exosomes are small double-membrane vesicles loaded with distinct cargos, particularly small non-coding RNAs called microRNAs, representative of each donor cell and secreted to affect the features of neighboring cells or recipient cells located further away, like in the case of metastas...
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
It is well established that obesity poses significant challenges to people's health and social wellbeing, with high prevalence of health problems, discrimination, and stigma associated with obesity in our society. While numerous studies have been published reporting positive impact of bariatric surgery on health outcomes, little is known about the effect of bariatric surgery on employment opportunities of the patients. In this issue of SOARD, an article entitled “Bariatric surgery improves the employment rate in people with obesity: 2-year analysis” by Mancini et al.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Invited Paired Editorial Source Type: research
We read with interest the recent paper by Wei, Jih-Hua et al.1 Briefly, authors evaluated cardiovascular disease risk after metabolic surgery in 392 type 2 diabetes mellitus patients using UKPDS score and investigated the efficacy of different bariatric/metabolic procedures on cardiovascular disease risk reduction.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Source Type: research
Authors: Zhu Y, Xiang J, Liu W, Cao Q, Zhou W Abstract Background and Aims: Laparoscopic approach is recommended as the first-choice option for simple ileocecal resections. However, there are no randomized trials that have focused on patients with Crohn's disease (CD) treated by laparoscopy and enhanced recovery pathway. The aim of the present study is to prospectively evaluate the feasibility, safety, and short-term outcomes of laparoscopy with enhanced recovery pathway for CD patients undergoing ileocecal resection. Methods: A consecutive cohort of 32 CD patients who underwent laparoscopic ileocecal resection...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
CONCLUSIONS: These suggested the beneficial effects of vitamin D supplementation in obesity-related diabetes rat, which may through VDR, IRS-1/p-IRS-1, and GluT4 signaling activation. PMID: 30531693 [PubMed - as supplied by publisher]
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
CONCLUSIONS: Women can be reassured that fertility drugs do not appear to significantly increase the risk of invasive ovarian, endometrial, breast or other cancers, while achieving a pregnancy at an earlier age is a significant protective factor. PMID: 30536354 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Based on the participants LBM profile, a reference table for LBM values was proposed. This reference will be useful to detect changes in the LBM compartment of individuals from the South Central Region of Italy, supporting health professionals during the process of diagnosing sarcopenia. PMID: 30536335 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
The Patient-Reported Outcomes Measurement Information System (PROMIS) assessment includes computerized adaptive tests (CATs) that assess function, pain, depression, and anxiety. The influence of mental health on patients' self-reported pain and function has not been explored using PROMIS in patients with symptomatic glenohumeral osteoarthritis.
Source: Journal of Shoulder and Elbow Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
CONCLUSION: The present study shows that using infliximab further increases the risk of malignant lymphoma in patients receiving methotrexate therapy.
. PMID: 30526810 [PubMed - as supplied by publisher]
Source: International Journal of Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Tags: Int J Clin Pharmacol Ther Source Type: research
Psoriasis is a systemic inflammatory disease associated with increased risk of comorbidities, such as psoriatic arthritis, Crohn's disease, malignancy, obesity, and cardiovascular diseases. These factors have a significant impact on the decision to use one therapy over another. The past decade has seen a paradigm shift in our understanding of the pathogenesis of psoriasis that has led to identification of new therapeutic targets. Several new drugs have gained approval by the US Food and Drug Administration, expanding the psoriasis armamentarium, but still a large number of patients continue to be untreated or undertreated.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Continuing medical education Source Type: research
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