Role of PI3K/Akt/NF- κB and GSK-3β pathways in the rat model of cardiopulmonary bypass-related lung injury.

CONCLUSION: The PI3K/Akt/NF-κB pathway played a role in CPB-related lung injury, possibly through mediating apoptosis in lungs. GSK-3β, a signaling effector that also participated in CPB-induced apoptosis in lungs, but was not regulated by the PI3K/Akt pathway in this context.
PMID: 29990867 [PubMed - as supplied by publisher]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - July 5, 2018 Category: Drugs & Pharmacology Authors: He M, Zhang Y, Xie F, Dou X, Han M, Zhang H Tags: Biomed Pharmacother Source Type: research