Impact of Aldehyde Dehydrogenase Activity on Gliomas

Publication date: July 2018Source: Trends in Pharmacological Sciences, Volume 39, Issue 7Author(s): Theodora Vasilogiannakopoulou, Christina Piperi, Athanasios G. PapavassiliouHigh-grade gliomas are primary brain tumors with a highly aggressive, invasive phenotype and dismal outcome. Targeting cell metabolism and cancer bioenergetics has emerged as a potential effective therapeutic approach. Selective aldehyde dehydrogenase isoenzyme activity regulates glioma tumor growth, invasiveness, and resistance to current treatments, and has potential as a therapeutic target.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research