Fabrication of tannic acid/poly(N-vinylpyrrolidone) layer-by-layer coating on Mg-based metallic glass for nerve tissue regeneration application

This study investigates the biocorrosion and biocompatibility of Mg-Zn-Ca metallic glass ribbon with Mg70Zn26Ca4 composition. For controlling biocorrosion, layer-by-layer coating of tannic acid/ poly(N-vinylpyrrolidone) was applied on Mg70Zn26Ca4 ribbon and characterized by SEM and FTIR. Immersion and potentiodynamic polarization test results indicated that coating significantly improved the corrosion resistance of Mg70Zn26Ca4. Schwann cells were selected for the cytocompatibility evaluation of samples due to their key role in peripheral nerve regeneration and ability to repair spinal cord injuries. The MTT assay and cell morphology results showed good biocompatibility for Mg70Zn26Ca4 metallic glass as a promising candidate for nerve regeneration and implantable nervous prosthetic devices.Graphical abstractEvaluation of magnesium-based metallic glass ribbon with tannic acid/poly(N-vinylpyrrolidone bilayer coating for nerve tissue engineering purposes.
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research