Atrial Fibrillation is Associated with Impaired Atrial Mitochondrial Energetics and Supercomplex Formation in Adults with Type 2 Diabetes

Publication date: Available online 31 May 2018Source: Canadian Journal of DiabetesAuthor(s): Georges N. Kanaan, David Patten, Calum Redpath, Mary-Ellen HarperAbstractBackgroundType 2 diabetes mellitus (T2DM) is a chronic progressive disease associated with increased risk for cardiovascular diseases (CVDs) and with impaired mitochondrial metabolism in cardiac and skeletal muscles. Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with significant morbidity and mortality. T2DM is also one of the prevalent concomitant diseases in patients with AF. During AF, myocardial energy demand is high due to electrical activity. To-date however, very little is known about the effects of AF on atrial muscle mitochondrial energetics.HypothesisWe hypothesized that pre-existing fibrillation or T2DM impacts atrial mitochondrial energetics and electron transport chain (ETC) supercomplexes.MethodsAtrial appendages were collected from consented patients with and without pre-existent AF undergoing coronary artery bypass graft (CABG) surgery. Mitochondrial functional analyses were conducted in permeabilized myofibers using high resolution respirometry.Results and conclusionResults show impaired complex I and II function in addition to impaired ETC supercomplex assembly in patients with diabetes and AF compared to patients with diabetes but without AF. There were no differences in mitochondrial content in atrial muscle between groups. There was a strong trend ...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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Authors: Al-Rawahi A PMID: 32489679 [PubMed]
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Authors: Yahaya TO, Ufuoma SB Abstract Single gene mutations have been implicated in the pathogenesis of a form of diabetes mellitus (DM) known as the maturity-onset diabetes of the young (MODY). However, there are diverse opinions on the suspect genes and pathophysiology, necessitating the need to review and communicate the genes to raise public awareness. We used the Google search engine to retrieve relevant information from reputable sources such as PubMed and Google Scholar. We identified 14 classified MODY genes as well as three new and unclassified genes linked with MODY. These genes are fundamentally embedde...
Source: Oman Medical Journal - Category: Middle East Health Tags: Oman Med J Source Type: research
Date of submission: July 1st 2020 Overall GPA: ~3.65 (3.7 by time of graduation) Science GPA: ~ 3.6 (not sure if A&P and statistics count here) Bio-Chem-Physics GPA: ~3.6 (3.7 after retakes) DAT score (include AA and all sections): Bio: 18, GC: 18, TS: 18, RC: 23, PAT: 19, AA: 20 (I'll be taking the American DAT as soon as I can [Sept?] and the Canadian DAT once again in Nov) State of Residence: Canada Undergrad Attended: York University... WAMC Canadian, First Time Applicant, Low DAT
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: What Are My Chances? WAMC Dental Source Type: forums
Abstract Objective: Autoimmune conditions tend to cluster in subjects with Addison's disease (AD) and probably also among their relatives. The aim of the study was to estimate the frequency of the endocrine gland-specific autoantibodies in first-degree relatives of patients with AD. Methods: Autoantibodies were investigated in 113 family members using RIA and ELISA assays. The control group comprised 143 age-matched volunteers. Results: Autoimmune diseases were diagnosed in 38.1% relatives. Hashimoto's thyroiditis was found in 20.3%, Graves' disease in 8.0%, vitiligo and type 1 diabetes in 3.5%, whereas ...
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Tags: Eur J Endocrinol Source Type: research
Fitbit is continuing its rapid trajectory into the medtech industry with a new Emergency Use Authorization from FDA. The San Francisco, CA-based company said the EUA is for a low-cost emergency ventilator to help address patients’ needs during the COVID-19 pandemic. The company said after seeing the need for ventilators, it applied its deep in-house expertise in advanced sensor development and hardware design to quickly create Fitbit Flow, an automatic resuscitator inspired by the MIT E-Vent Design Toolbox and based on specifications for Rapidly Manufactured Ventilation Systems. Fitbit said during develop...
Source: MDDI - Category: Medical Devices Tags: COVID-19 Business Source Type: news
Publication date: Available online 3 June 2020Source: Pharmacological ResearchAuthor(s): Ana Margarida da Silva Figueiredo, Ermelindo Carreira Leal, Eugénia Maria Lourenço de Carvalho
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 3 June 2020Source: Pharmacological ResearchAuthor(s): Peyman Nowrouzi-Sohrabi, Reza Tabrizi, Shahla Rezaei, Fatemeh Jafari, Kamran Hesami, Mehdi Abedi, Mohammad Jalali, Pedram Keshavarzi, Saeed Shahabi, Ali Asghar Kolahi, Kristin Carson-Chahhoud, Amirhossein Sahebkar, Saeid Safiri
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 4 June 2020Source: Canadian Journal of CardiologyAuthor(s): Kerrin M. Green, Sohrab R. Lutchmedial
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 4 June 2020Source: Canadian Journal of CardiologyAuthor(s): Alice Virani, Gurmeet Singh, David Bewick, Jean-François Légaré, Chi-Ming Chow, Howard Leong-Poi, Brian Clarke, Simone Cowan, Christopher Fordyce, Kenneth Gin, Benny Lau, Sean Virani, David Wood, Andrew Krahn, Anne Fournier, Anil Gupta, Sean Hardiman, Simon Jackson, John Sapp, Yoan Lamarche
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
More News: Arrhythmia | Atrial Fibrillation | Canada Health | Cardiac Arrhythmia | Cardiology | Cardiovascular | Cardiovascular & Thoracic Surgery | Coronary Artery Bypass Graft | Diabetes | Diabetes Mellitus | Diabetes Type 2 | Endocrinology | Heart | Mitochondrial Disease