Prediction of the Omp16 Epitopes for development of an epitope based Vaccine against Brucellosis.

Prediction of the Omp16 Epitopes for development of an epitope based Vaccine against Brucellosis. Infect Disord Drug Targets. 2018 Jul 09;: Authors: Rezaei M, Rabbani-Khorasgani M, Zarkesh-Esfahani SH, Emamzadeh R, Abtahi H Abstract Brucellosis is an infectious disease caused by Brucella bacteria that cause disease in animals and humans. Brucellosis is one of the most common zoonotic diseases transmitted animals -to-human through direct contact with infected animals and also consumption of unpasteurized dairy products. Due to wide incidence of brucellosis in Iran and economical costs in industry animal husbandry, Vaccination is best way to prevent of this disease. All of available commercial vaccines against brucellosis are derived from live attenuated strains of Brucella. But because of disadvantage of live attenuated vaccines, protective subunit vaccine against Brucella may be a good candidate for production of new recombinant vaccines based on Brucella outer membrane protein (OMP) antigens. In the present study, comprehensive bioinformatics analysis has been conducted on prediction software to predict T and B cell epitopes, the secondary and tertiary structures and antigenicity of Omp16 antigen and the validation of used software confirmed by experimental results. The final epitope prediction results have proposed that the three epitopes were predicted for the Omp16 protein with antigenicity ability. We hypothesized that these epi...
Source: Infectious Disorders Drug Targets - Category: Infectious Diseases Authors: Tags: Infect Disord Drug Targets Source Type: research