{beta}-Hydroxybutyrate Detection with Proton MR Spectroscopy in Children with Drug-Resistant Epilepsy on the Ketogenic Diet [PEDIATRICS]

CONCLUSIONS: Clinical MR spectroscopy in pediatric patients on the ketogenic diet demonstrated measurable β-hydroxybutyrate, with a strong correlation to β-hydroxybutyrate blood levels. These findings may serve as an effective tool for noninvasive monitoring of ketosis in this population. An inverse correlation between serum β-hydroxybutyrate levels and brain tissue N-acetylaspartate suggests that altered amino acid handling contributes to the antiepileptogenic effect of the ketogenic diet.

http://www.ajnr.org/cgi/content/abstract/39/7/1336?rss=1

Source: American Journal of Neuroradiology - July 9, 2018 Category: Radiology Authors: Wright, J. N., Saneto, R. P., Friedman, S. D. Tags: PEDIATRICS Source Type: research