Prognostic Value of Somatosensory-evoked Potentials and CT Scan Evaluation in Acute Traumatic Brain Injury

Background:The aim of this study is to assess whether a complete analysis of all early cortical somatosensory-evoked potentials (SEPs) components and computed tomography (CT) scan features can provide a better prognostic measure than the early cortical component N20/P25 alone, in patients with severe head injury. Materials and Methods:We studied 81 consecutive patients admitted to intensive care unit with diagnosis of severe head injury. All patients underwent neurophysiological assessment with SEPs and electroencephalography within the first 6 days after trauma. The marginal effect of each variable on Glasgow Outcome Scale score was evaluated by using univariate measures of association. We fit a cumulative logit model by maximum likelihood, and the partial effect of each variable was assessed by likelihood ratio test. We performed variable selection by forward stepwise, according to the Akaike information criterion. Results:Our final cumulative logit model including SEPs primary complex (pN20/fP20/cP22), SEPs middle latency (N30/P45/N60), and CT scan hypodensity values showed a significantly increased predictive power of Glasgow Outcome Scale, compared with pN20 alone (P
Source: Journal of Neurosurgical Anesthesiology - Category: Anesthesiology Tags: Clinical Investigations Source Type: research