Vaccine maker PaxVax tackles the unmet need posed by chikungunya virus

Transmitted by the same mosquitoes that spread Zika virus and dengue fever, the chikungunya virus is named for an African word meaning “to become contorted.” People infected with the alphavirus are afflicted with lasting joint pain that causes their backs to hunch over, according to the World Health Organization. The virus, which has cropped up in Africa, Asia, Europe and the Caribbean, has no vaccine. Instead, the Centers for Disease Control &Prevention recommends that people traveling to countries with chikungunya virus use insect repellent and wear long sleeves and pants. But Nima Farzan thinks a vaccine in his company’s pipeline could help change that. Get the full story at our sister site, Drug Delivery Business News. The post Vaccine maker PaxVax tackles the unmet need posed by chikungunya virus appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Clinical Trials Pharmaceuticals National Institutes of Health (NIH) paxvax Source Type: news

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de Castro Faria Neto HC, Boechat N, Rehen SK, Brüning K, Bozza FA, Bozza PT, Souza TML Abstract Chikungunya virus (CHIKV) causes a febrile disease associated with chronic arthralgia, which may progress to neurological impairment. Chikungunya fever (CF) is an ongoing public health problem in tropical and subtropical regions of the world, where control of the CHIKV vector, Aedes mosquitos, has failed. As there is no vaccine or specific treatment for CHIKV, patients receive only palliative care to alleviate pain and arthralgia. Thus, drug repurposing is necessary to identify antivirals against CHIKV. CHIKV RNA p...
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research
Conclusion The results obtained from this research shows, in general, the fragility in the social and political infrastructure necessary to improve the living conditions of populations, particularly those that depend on family agriculture in drought prone areas. The conditions of social, economic and environmental vulnerabilities presented in the region can be amplified by the drought process, and can aggravate the impacts resulting drought events, thus disadvantaging the population of this region, as shown in the Fig. 1. The general perception of the interviewees of the health sector shows an agreement with what is found...
Source: PLOS Currents Disasters - Category: International Medicine & Public Health Authors: Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 010 Peer Reviewer: Dr Jennifer Ho, ID physician QLD, Australia You are an ED doc working in Perth over schoolies week. An 18 yo man comes into ED complaining of fever, rash a “cracking headache” and body aches. He has just hopped off the plane from Bali where he spent the last 2 weeks partying, boozing and running amok. He got bitten by “loads” of mosquitoes because he forgot to take insect repellent. On e...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine arthralgia dengue fever rash Source Type: blogs
Abstract The viruses responsible for mosquito-borne diseases are on an exploring mode, expanding their horizon, adapting to the situation and comfortably making their presence felt globally, from South Africa to Asia, Europe and United States. The current global scenario and recent documentations indicate towards the real monsters, outbreak of Zika, dengue and chikungunya viruses. Zika, dengue and chikungunya viruses, all three are positive sense single-stranded RNA arbovirus and so their initial symptoms are almost 80% similar and all three are spread by mosquitos which bite during the day. Zika virus is more dan...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research
Public health officials in Brazil suspect that a small yellow fever outbreak in Minas Gerais, a populous landlocked state adjacent to São Paulo state, has infected 110 people and killed 30, according to a Friday report. There is a vaccine for yellow fever, but because the outbreak is taking hold in areas with low vaccination rates, officials are concerned that the disease could continue to spread beyond the state’s borders and cause a larger epidemic, according to the World Health Organization. Yellow fever is spread by the same mosquito that spreads Zika virus, dengue fever and chikungunya.&nbs...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
This article is part HuffPost’s Project Zero campaign, a yearlong series on neglected tropical diseases and efforts to eliminate them. More than 1 billion people on the planet suffer from illnesses that the world pays little attention to. Neglected tropical diseases are a group of at least 18 diseases that primarily affect people living in poverty in tropical regions of the world and are virtually unknown elsewhere, according to the World Health Organization. These are diseases like river blindness, which has infected 18 million people worldwide and caused blindness in 270,000 people; or...
Source: Science - The Huffington Post - Category: Science Source Type: news
  Zika continues to be the virus of the day for returning travelers, but there are several other diseases that we need to consider in these patients when they present to us in the emergency department. Chikungunya is epidemic in many of the same countries as Zika and can be even more devastating. And Avian and MERS-CoV is still present in many countries. Unlike patients infected with Zika virus, these patients do require isolation to protect our health care staff from infection. Chikungunya Chikungunya, which means “to walk bent over,” was likely endemic but unrecognized in the United States before the mos...
Source: EPMonthly.com - Category: Emergency Medicine Authors: Tags: Uncategorized Source Type: news
As if disease-carrying mosquitoes weren’t bad enough in the first place, scientists have found the pesky insects may be able to infect us with two viruses at the same time.  A small lab study that exposed mosquitoes to blood infected with varying combinations of dengue, Zika and chikungunya proved that the mosquitoes were able to pick up two viruses — Zika and chikungunya — at the same time. The results suggest that human beings could be infected with both the Zika virus and the chikungunya virus in one bite, but researchers need to conduct more studies to find out how this affects a person&rsqu...
Source: Science - The Huffington Post - Category: Science Source Type: news
LONDON (Thomson Reuters Foundation) - “Lazy mosquitoes” are the reason why women, who tend to spend more time at home than men, are more likely to be infected by chikungunya, a painful mosquito-borne viral disease which spreads the same way as Zika, researchers said on Monday. Chikungunya, which is commonly transmitted by the daytime-biting aedes aegypti mosquito, can cause debilitating symptoms including fever, headache and severe joint pain lasting months. A new study, published in the Proceedings of the National Academy of Sciences, analyzed a 2012 outbreak of chikungunya in the Bangladeshi village of Palpar...
Source: Science - The Huffington Post - Category: Science Source Type: news
Funding Opportunity ID: 287737 Opportunity Number: CDC-RFA-CK11-11060501SUPP16 Opportunity Title: CDC Mexico Co-Ag for Surveillance &EpidemiologyOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCategory Explanation: CFDA Number(s): 93.283Eligible Applicants: Others (see text field entitled "Additional Information on Eligibility" for clarification)Additional Information on Eligibility: Single Source competition for FUMEC. Directed award for bi-national vector surveillance efforts.Agency Code: HHS-CDC-N...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding
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