Deficiency of parkin suppresses melanoma tumor development and metastasis through inhibition of MFN2 ubiquitination

Parkin, a critical gene of Parkinson's disease, is involved in the development of numerous cancers. However, the effect of parkin deficiency on melanoma growth and metastasis has not been reported. We showed that the tumor size and number of surface lung metastases, and expression of tumor growth and metastasis marker proteins were significantly lower in parkin-KO mice than those observed in non-transgenic controls. In an in vitro study, we also showed that parkin siRNA inhibited cell growth and migration of B16F10 and SK-Mel-28 cells.

Source: Cancer Letters - July 5, 2018 Category: Cancer & Oncology Authors: Yong Sun Lee, Yu Yeon Jung, Mi Hee Park, In Jun Yeo, Hyung Sik Im, Kyung Tak Nam, Hae Deun Kim, Shin Kook Kang, Ju Koung Song, Yu Ri Kim, Dong-Young Choi, Pil-Hoon Park, Sang Bae Han, Jae Suk Yun, Jin Tae Hong Tags: Original Articles Source Type: research