Some existing anti-cancer drugs may act in part by targeting RNA, study shows

(Scripps Research Institute) The research offers another approach for tackling diseases that have been considered 'undruggable,' including amyotrophic lateral sclerosis (ALS), muscular dystrophy, cystic fibrosis and certain cancers.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Jaakko Hentil ä, Tuuli A. Nissinen, Ayhan Korkmaz, Sanna Lensu, Mika Silvennoinen, Arja Pasternack, Olli Ritvos, Mustafa Atalay, Juha J. Hulmi
Source: Frontiers in Physiology - Category: Physiology Source Type: research
This study describes the frequency and nature of industry sponsorship of Australian health consumer organizations and examines the link between sponsorship of the most highly funded organizations and manufacturers' requests for public reimbursement of products for related health conditions. We downloaded 130 transparency reports covering the period January 2013 to December 2016 from the website of Medicines Australia and carried out a descriptive analysis. For the most heavily funded organizations and their sponsors, we examined Public Summary Documents of the Pharmaceutical Benefits Advisory Committee to identify relevant...
Source: International Journal of Health Services - Category: Health Management Tags: Int J Health Serv Source Type: research
Publication date: Available online 18 January 2019Source: Regulatory Toxicology and PharmacologyAuthor(s): John E. Doe, Alan R. Boobis, Vicki Dellarco, Penelope A. Fenner-Crisp, Angelo Moretto, Timothy P. Pastoor, Rita S. Schoeny, Jennifer G. Seed, Douglas C. WolfAbstractDevelopments in the understanding of the etiology of cancer have undermined the 1970s concept that chemicals are either “carcinogens” or “non-carcinogens”. The capacity to induce cancer should not be classified in an inflexible binary manner as present (carcinogen) or absent (non-carcinogen). Chemicals may induce cancer by three cat...
Source: Regulatory Toxicology and Pharmacology - Category: Toxicology Source Type: research
Cancer patients are at lower risk of developing Parkinson ’s disease (PD) compared with the general population. One explanation is the negative association between smoking and PD, but PD risk is also lower for cancers not related to smoking. Another explanation is survival bias where death from cancer may act as a competing risk. We conducted a large pop ulation-based case-control study in Denmark and investigated whether cancer diagnosis reduced the risk of developing PD even after adjusting for important risk factors including smoking, physical activity, and lifetime oestrogen status. Using probabilistic bias analy...
Source: Neuroepidemiology - Category: Epidemiology Source Type: research
Conclusions: Ethnic and regional differences in the prevalence of genetic muscle disorders need to be considered in service delivery planning, evaluation, and decision making.Neuroepidemiology 2019;52:128 –135
Source: Neuroepidemiology - Category: Epidemiology Source Type: research
We examined the effect of the ACA on breast cancer screening and diagnosis at a Los Angeles safety net hospital.MethodsWe performed a retrospective review of breast cancer patients treated at our institution. We compared two cohorts: patients diagnosed with breast cancer in the years 2011-2012 (pre-ACA) vs. 2015-2016 (post-ACA).ResultsThere were no differences in number of screening mammograms performed, age at diagnosis, mammography-detected cancers, or clinical stage at diagnosis. There was a significant decrease in the number of patients who reported as self-pay (34% vs. 6%, p
Source: The American Journal of Surgery - Category: Surgery Source Type: research
CONCLUSION: The Healthy Lunch Box sessions were effective in improving parental knowledge and practices related to fruit and vegetables and parental confidence with packing a healthy lunch box. SO WHAT?: This short intervention could be a useful component of a portfolio of interventions to support parents with knowledge and resources to pack a healthy lunch box for their children. PMID: 30648332 [PubMed - in process]
Source: Health Promotion Journal of Australia - Category: International Medicine & Public Health Tags: Health Promot J Austr Source Type: research
A  lawsuitinvolving a 49-year-old male with colon cancer has demonstrated the need for physicians to thoroughly read radiology reports and for radiologists to effectively relay image interpretations.The patient had undergone a CT scan for pre-procedure workup for his extracorporeal shock wave lithotripsy to remove kidney stones. The scan showed a possible indication of colon cancer, and the radiologist had made note of those findings on the second page of the report that was sent to the urologist that same day. However, the urologist neglected to read the second page, and 19 months later, the patient was diagnosed wit...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
Authors: Bingener-Casey J, Bauer BA, Cutshall SM, Skaran PE, Cheville AL, Sloan JA Abstract PMID: 30646679 [PubMed - in process]
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
Authors: Pansadoro V, Brassetti A Abstract PMID: 30646676 [PubMed - in process]
Source: Minerva Chirurgica - Category: Surgery Tags: Minerva Chir Source Type: research
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