Gene expression profile of Dclk1+ cells in intestinal tumors

Accumulating evidence has shown the existence of tumor stem cells with therapeutic potential. Previously, we reported that doublecortin like kinase 1 (Dclk1) marks tumor stem cells but not normal stem cells in the intestine of ApcMin/+ mice, and that Dclk1- and Lgr5-double positive tumor cells are the tumor stem cells of intestinal tumors.

Source: Digestive and Liver Disease - June 22, 2018 Category: Gastroenterology Authors: Yuichi Yamaga, Akihisa Fukuda, Yuki Nakanishi, Norihiro Goto, Yoshihide Matsumoto, Takuto Yoshioka, Takahisa Maruno, Tsutomu Chiba, Hiroshi Seno Tags: Alimentary Tract Source Type: research