Do Death Certificates Underestimate the Burden of Rare Diseases? The Example of Systemic Lupus Erythematosus Mortality, Sweden, 2001-2013.
The objective of this study was to determine the completeness of reporting systemic lupus erythematosus (SLE) as a cause of death. METHODS: In 2017, we linked data on a Swedish population-based cohort (the Swedish Lupus Linkage, 2001-2013) comprising people with SLE (n = 8560) and their matched general population comparators (n = 37 717) to data from the Cause of Death Register. We reviewed death records of deceased people from the cohort (n = 5110) and extracted data on patient demographic characteristics and causes of death. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) for not reporting SLE as a cause of death by using multivariable-adjusted logistic regression models. RESULTS: Of 1802 deaths among SLE patients in the study, 1071 (59%) did not have SLE reported on their death records. Most SLE decedents were aged 75-84 at death (n = 584, 32%), female (n = 1462, 81%), and born in Nordic countries (n = 1730, 96%). Decedents aged ≥85 at death were more likely to have SLE not reported on their death records than were decedents aged
This study investigates the distribution of femoral metastases in cancer patients, specifically addressing the incidence of distal femoral metastases. PET/CT examinations routinely extend only to mid-thigh level, precluding detection of distal metastases. We found a total of 208 femoral metastases in 112 patients. 30% had distal femoral metastases in addition to other areas of involvement. 7% of patients with femoral metastases had only distal femur disease. 6 patients had distal pathologic fractures. Exclusion of the distal femur during PET/CT may result in a missed or delayed diagnosis that could contribute to the develo...
In conclusion, implementation of FLS was associated with a reduced risk of recurrent fracture, indicating that FLSs should be included routinely at hospitals treating fracture patients.This article is protected by copyright. All rights reserved.
Authors: Xu H, Dong L, Bin Z, Yansong H, Shaofeng L, Chang L, Chen C, Changli W Abstract Despite the excellent efficacy and low toxicity of photoresponse therapy, which has attracted considerable attention for use in non-small cell lung cancer (NSCLC) therapy, unsatisfactory cellular permeability, and instability, both in vitro and in vivo have limited further clinical applications of indole cyanine photosensitizers. Here, we explore the supramolecular self-assembly of a 'hyalurosome' that is mediated by calcium phosphate nanonuclei. Through hyaluronate-mediated CD44 targeting, the constructed hyalurosome...
To identify the independent risk factors of concurrent endometrial cancer among women with endometrial hyperplasia and build the clinical prediction model incorporating the clinical and pathological markers.
We aim to present a modified colpocleisis technique for management of a stage 4 POP after a radical cystectomy/ anterior pelvic exenteration. Additionally, we will briefly review urothelial cancer and surgical management as it relates to gynecology.
To determine the adherence to the recommended practices for performing a risk-reducing bilateral salpingo-oophorectomy (RRBSO) as described by the American College of Obstetricians and Gynecologists and Society of Gynecologic Oncology. We sought to determine if adherence differed by type of training i.e., gynecologic oncologists versus benign gynecologists. Additionally, we aimed to determine the incidence of ovarian cancer diagnosed at the time of RRBSO in a large cohort of patients with a BRCA mutation.
The increasing number of cancer patients and prolonged periods of illness have led to an increase in nurses' stress and various other problems. This research aimed to identify the stress resulting from caring for cancer patients and the methods for coping with stress among cancer care nurses. The research subjects were 180 clinical nurses caring for cancer patients in a hospital in Korea. Stress caused by excessive workloads, inappropriate compensation, and interpersonal conflicts with physicians was high. There was a difference in stress according to age. Coping strategies differed according to religion, education, occupa...
How do alcohol consumption and smoking interact with familial risk for breast cancer?Breast Cancer Research
Berger's disease should be considered an imperative cause of renal dysfunction in thalassemia. This case highlights the importance of early diagnosis, clinicopathological correlation, and prompt therapy in Berger's disease. AbstractBerger ’s disease should be considered an imperative cause of renal dysfunction in thalassemia. This case highlights the importance of early diagnosis, clinicopathological correlation and prompt therapy in Berger's disease.
A two ‐stage multicomponent parenchymal sparing surgical strategy (anatomical extended on left hepatic vein 2‐nd segment liver resection and R1vascular approach) allows the successful resection of synchronous multiple bilobar CRC metastases. AbstractA two ‐stage multicomponent parenchymal sparing surgical strategy (anatomical extended on left hepatic vein 2‐nd segment liver resection and R1vascular approach) allows the successful resection of synchronous multiple bilobar CRC metastases.