Decreased clinical pregnancy and live birth rates after short interval from delivery to subsequent assisted reproductive treatment cycle

AbstractSTUDY QUESTIONDoes the interval from delivery to initiation of a subsequent ART treatment cycle impact clinical pregnancy or live birth rates?SUMMARY ANSWERAn interval from delivery to treatment start of<6 months or ≥24 months is associated with decreased likelihood of clinical pregnancy and live birth.WHAT IS KNOWN ALREADYShort interpregnancy intervals are associated with poor obstetric outcomes in the naturally conceiving population prompting birth spacing recommendations of 18 –24 months from international organizations. Deferring a subsequent pregnancy attempt means a woman will age in the interval with an attendant decline in her fertility.STUDY DESIGN, SIZE, DURATIONRetrospective analysis of the Society for Assisted Reproductive Technology Clinical Outcome Reporting System (SARTCORS) cohort containing 61 686 ART cycles from 2004 to 2013.PARTICIPANTS/MATERIALS, SETTING, METHODSThe delivery-to-cycle interval (DCI) was calculated for patients from SARTCORS with a history of live birth from ART who returned to the same clinic for a first subsequent treatment cycle. Generalized linear models were fit to determine the risk of clinical pregnancy and live birth by DCI with subsequent adjustment for factors associated with outcomes of interest. Predicted probabilities of clinical pregnancy and live birth were generated from each model.MAIN RESULTS AND THE ROLE OF CHANCEA DCI of<6 months was associated with a 5.6% reduction in probability of clinical pregnancy (...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research