Antitumor Activity and Mechanism of a Reverse Transcriptase Inhibitor, Dapivirine, in Glioblastoma

Conclusion: In summary, in our study dapivirine exposure induces stress, resulting in JNK and PI3K/Akt pathway activation through diminished inhibition of the apoptosis and autophagy cascade in U87 GBM cells, which inhibits cell growth in vitro and in vivo.

Source: Journal of Cancer - June 20, 2018 Category: Cancer & Oncology Authors: Weiwen Liu, Xian-lu Song, Shan-chao Zhao, Minyi He, Hai Wang, Ziyang Chen, Wei Xiang, Guozhong Yi, Songtao Qi, Yawei Liu Tags: Research Paper Source Type: research