Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions

Conclusion: Our study establishes sheep as a novel animal model for ultrasound-mediated BBB opening and highlights opportunities and challenges in using this model. Moreover, as sheep develop an AD-like pathology with aging, they represent a large animal model that could potentially complement the use of non-human primates.

Source: Theranostics - June 20, 2018 Category: Molecular Biology Authors: Matthew Pelekanos, Gerhard Leinenga, Mostafa Odabaee, Maryam Odabaee, Siamak Saifzadeh, Roland Steck, J ü rgen G ö tz Tags: Research Paper Source Type: research