Intermittent Hypoxia Exacerbates Increased Blood Pressure in Rats with Chronic Kidney Disease.

Intermittent Hypoxia Exacerbates Increased Blood Pressure in Rats with Chronic Kidney Disease. Am J Physiol Renal Physiol. 2018 Jun 13;: Authors: Riggs JL, Pace CE, Ward HH, Gonzalez Bosc LV, Rios L, Barrera A, Kanagy NL Abstract Kidney injury and sleep apnea (SA) are independent risk factors for hypertension. Exposing rats to intermittent hypoxia (IH) to simulate SA increases blood pressure while adenine feeding causes persistent kidney damage to model chronic kidney disease (CKD). We hypothesized that exposing CKD rats to IH would exacerbate the development of hypertension and renal failure. Male Sprague-Dawley rats were fed a 0.2% adenine or control diet until blood urea nitrogen (BUN) was > 120 mg/dL in adenine fed rats (14 {plus minus} 4 days). After two weeks recovery on normal chow, rats were exposed to IH (20 exposures/hr of 5% O2/5% CO2 7 hr/day) or control conditions for six weeks. Mean arterial pressure (MAP) was monitored with telemeters and plasma and urine samples were collected weekly to calculate creatinine clearance as an index of glomerular filtration rate (GFR). Prior to IH, adenine-fed rats had higher blood pressure than rats on control diet. IH treatment increased MAP in both groups and after six weeks MAP in the CKD/IH rats > CKD/Air rats = Control/IH rats > Control/Air rats. Kidney histology revealed crystalline deposits, tubule dilation and interstitial fibrosis in both CKD groups. IH caused no additional kidney damage. P...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research

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Abstract Obstructive sleep apnea (OSA) is characterized by recurrent episodes of pharyngeal collapse during sleep resulting in intermittent hypoxia (IH), and is associated with high incidence of hypertension and accelerated renal failure. In rodents, endothelin-1 (ET-1) contributes to IH-induced hypertension, and ET-1 levels inversely correlate with glomerular filtration rate (GFR) in end-stage chronic kidney disease (CKD) patients. Therefore, we hypothesized that a dual ET receptor antagonist, macitentan (Actelion Pharmaceuticals) will attenuate and reverse hypertension and renal dysfunction in a rat model of com...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
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