Capsule endoscopy for patients with coeliac disease.

Capsule endoscopy for patients with coeliac disease. Expert Rev Gastroenterol Hepatol. 2018 Jun 10;: Authors: Chetcuti Zammit S, Sidhu R, Sanders DS Abstract INTRODUCTION: Coeliac disease is an autoimmune mediated condition in response to gluten. A combination of innate and adaptive immune responses results in villous shortening in the small bowel which can be morphologically picked up on capsule endoscopy. Small bowel capsule endoscopy is the only imaging modality that can provide mucosal views of the whole length of the small bowel whilst histology is generally limited to the proximal small bowel. Radiological modalities are not designed to pick up changes in villous morphology. Areas covered: In this review, we provide a comprehensive analysis on the justified use of small bowel capsule endoscopy in the assessment of patients with coeliac disease, compare small bowel capsule endoscopy to histology, serology and symptomatology and provide an overview on automated quantitative analysis that has been applied in the detection of coeliac disease. We also provide insight into future work on small bowel capsule endoscopy in relation to coeliac disease. Expert commentary: Small bowel capsule endoscopy has opened up new avenues for the diagnosis and monitoring of patients with coeliac disease. However larger studies with new and established coeliac disease patients and with greater emphasis on morphological features on small bowel capsule ...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research