Cancer-associated fibroblasts promote gastric tumorigenesis through EphA2 activation in a ligand-independent manner

ConclusionCAFs may contribute to gastric tumorigenesis by activating EphA2 signaling pathway in a ligand-independent manner. Our results suggest that ligand-independent activation of EphA2 was triggered by VEGF released from CAF-CM. Our result may partially explain why ligand-dependent tumor suppressor roles of EphA2 are not evident in gastric cancer despite the prominent level of ephrinA1.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research