Plasminogen activator system homeostasis and its dysregulation by ethanol in astrocyte cultures and the developing brain.

In conclusion, astrocyte PA system may play a major role in the modulation of neuronal plasticity; ethanol-induced upregulation of tPA levels and plasmin activity may be responsible for altered neuronal plasticity in FASD.
PMID: 29885422 [PubMed - as supplied by publisher]

Source: Neuropharmacology - June 6, 2018 Category: Drugs & Pharmacology Authors: Wilhelm CJ, Hashimoto JG, Roberts ML, Zhang X, Goeke CM, Bloom SH, Guizzetti M Tags: Neuropharmacology Source Type: research