Preeclampsia and the cardiovascular system: An update

Preeclampsia, an important cause of maternal mortality and morbidity worldwide, is defined as the new onset of hypertension in pregnancy after 20 weeks ’ gestation with associated proteinuria, maternal organ dysfunction or fetal growth restriction [1–3]. The incidence of preeclampsia is estimated to be between 3 and 10% of all pregnancies. While maternal death due to preeclampsia is less common in developed countries, maternal morbidity is high and is a major contributor to intensive care unit admissions—especially given that preeclampsia is more common with advanced maternal age, obesity and other medical co-morbidities.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research

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In the past three decades, the incidence of preeclampsia, characterized by hypertension, proteinuria and end organ damage, has significantly increased in the U.S., in association with an increase in maternal weight. There is a gap in our understanding regarding how obesity influences preeclampsia. Ankiryn-repeat-and-SOCS-box-containing-protein 4 (ASB4) contributes to the differentiation of trophoblast stem cells into the giant trophoblast cells necessary for embryo implantation in mice. ASB4-null females develop preeclampsia-like phenotypes during pregnancy.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session V Source Type: research
ConclusionHT associated with post-partum AKF is relatively frequent, secondary to HELLP syndrome and tubular necrosis. The prognosis depends on the early diagnosis and treatment and on the preventive measures during the pregnancy (self-measurement of blood pressure monitoring or ambulatory measurement of blood pressure, screening for proteinuria and uric acid analysis).
Source: Archives of Cardiovascular Diseases Supplements - Category: Cardiology Source Type: research
Conclusion: Periodontal disease is significantly and positively correlated with increased risk of hypertension in Chinese population, and exact mechanisms of this association should be explored in future. Introduction Periodontal disease is a complex polymicrobial inflammation, including gingivitis and periodontitis. According to the 2015 Global Burden of Disease (GBD) study, the prevalence of severe chronic periodontitis in 2015 has reached 616 million (Kassebaum et al., 2017). In China, the periodontal disease standardized DALYs rate has risen from 24.7 in 1990 to 25.7 in 2013 according to the data from 2013 GBD ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Introduction: Preeclampsia is a hypertensive disorder combined with proteinuria and occurs only during pregnancy. The condition is potentially dangerous for the mother and the foetus, and is one of the most common reasons for maternal and foetal mortality and morbidity globally. The aetiology is still unknown, but many risk factors are identified. Risk of preeclampsia is higher among nulliparous women compared with parous women. Advanced maternal age, obesity, diabetes mellitus and pre-pregnancy hypertension increase the risk of preeclampsia.
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - Category: OBGYN Authors: Tags: Session 10 – Obstetrics: Hypertension Source Type: research
Publication date: July 2018Source: Pregnancy Hypertension, Volume 13Author(s): Genevieve Eastabrook, Tuba Aksoy, Samantha Bedell, Debbie Penava, Barbra de VrijerAbstractPreeclampsia is a serious pregnancy condition defined as new-onset hypertension and proteinuria, commonly characterized as either early, ‘placental’, or late onset, ‘maternal’, using a cut-off of 34 weeks gestation. However, it may be more useful to differentiate between the vascular remodelling and placental invasion vs. inflammation and metabolic pathophysiology that underlie these forms of preeclampsia. Due to rising rates of ob...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
AbstractAimTo describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age.MethodsWe analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c  >  8.0%; BMI ≥ 35; systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg; microalbuminuria/proteinuria; use of statins, ACE inhibitors, ARB; use of diabetes drugs other than metformin/insulin.ResultsThe proportion of T2D cases increased from 30.8...
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
Publication date: July 2017 Source:Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, Volume 9 Author(s): Anne Cathrine Staff Cardiovascular disease (CVD) is the major global killer, for women and men alike, and also the non-communicable disease that removes most days of life. Pregnancy is an underused stress test to identify women at high risk for CVD at a young age. In this overview, the associations between preeclampsia and other placenta-related pregnancy complications, and future maternal CVD are summarized. Large population based studies and meta-analyses concluded that women with a h...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Conclusions: These results suggest that there is a seasonal driver for PE, with effects that are not modified by parity, latitude, fetal sex, or smoking. https://doi.org/10.1289/EHP963 Received: 14 August 2016 Revised: 24 January 2017 Accepted: 25 January 2017 Published: 29 June 2017 Address correspondence to C.R. Weinberg, Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709 USA. Telephone: (919) 541-4927. Email: weinber2@niehs.nih.gov Supplemental Material is available online (https://doi.org/10.1289/EHP963). The authors declare they h...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Source Type: research
Publication date: January 2017 Source:Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, Volume 7 Author(s): James J. Walker Preeclampsia is a disease of theories. There is much that we know, much that we know we don’t know and even more that we don’t know we don’t know. Despite being known since ancient times, we still do not understand the causes or progression of pre-eclampsia. But that does not stop us from thinking we do. With the discovery of proteinuria and high blood pressure, all the complications, including the placenta damage,.were explained on the renal problem...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
Publication date: January 2017 Source:Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health, Volume 7 Author(s): Pierre-Yves Robillard Eclampsia (together with epilepsy) being the first disease ever written down since the beginning of writings in mankind 5000years ago, we will make a brief presentation of the different major steps in comprehension of pre-eclampsia. (1) 1843 Lever, description of proteinuria, (2) 1903 Cooks & Briggs discovery of gestational hypertension (7years after the invention of the inflatable arm band in 1896 by a young 31year-old Italian physician Riva-Rocci), (3) End...
Source: Pregnancy Hypertension: An International Journal of Womens Cardiovascular Health - Category: OBGYN Source Type: research
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