Small Delivery Vehicles of siRNA for Enhanced Cancer Targeting.

Small Delivery Vehicles of siRNA for Enhanced Cancer Targeting. Biomacromolecules. 2018 Jun 04;: Authors: Kim HJ, Yi Y, Kim A, Miyata K Abstract Small interfering RNA (siRNA) drugs have been considered to treat various diseases in major organs. However, siRNA drugs developed for cancer therapy are hindered from proceeding to clinics. To date, various delivery formulations have been developed from cationic lipids, polymers, and/or inorganic nanoparticles for systemic siRNA delivery to solid tumors. Most of these delivery vehicles do not generate small particle sizes and pharmacokinetics required for accumulation in target cancer cells, compared with clinically tested anticancer drug-loaded polymeric micelles. This review describes the significance of small, long-circulating vehicles for efficient delivery of siRNA to cancer tissues via the enhanced permeability and retention (EPR) effect. We summarize recent biological evidence that supports the size effect of delivery vehicles in tumor microenvironments and introduce the promising strategies for construction of small vehicles with a size of 10 to 50 nm. We then discuss the feasibility of these delivery vehicles with respect to translation to clinical trials. PMID: 29864287 [PubMed - as supplied by publisher]
Source: Biomacromolecules - Category: Biochemistry Authors: Tags: Biomacromolecules Source Type: research