Zinc Inhibits Phosphate-Induced Vascular Calcification through TNFAIP3-Mediated Suppression of NF-{kappa}B

Conclusions Zinc supplementation ameliorates phosphate-induced osteo-/chondrogenic transdifferentiation of VSMCs and vascular calcification through an active cellular mechanism resulting from GPR39-dependent induction of TNFAIP3 and subsequent suppression of the NF-B pathway. Zinc supplementation may be a simple treatment to reduce the burden of vascular calcification in CKD.

Source: Journal of the American Society of Nephrology : JASN - May 31, 2018 Category: Urology & Nephrology Authors: Voelkl, J., Tuffaha, R., Luong, T. T. D., Zickler, D., Masyout, J., Feger, M., Verheyen, N., Blaschke, F., Kuro-o, M., Tomaschitz, A., Pilz, S., Pasch, A., Eckardt, K.-U., Scherberich, J. E., Lang, F., Pieske, B., Alesutan, I. Tags: Basic Research Source Type: research