Oligopeptides for Immunotherapy Approaches in Ovarian Cancer Treatment.

Oligopeptides for Immunotherapy Approaches in Ovarian Cancer Treatment.
Curr Drug Discov Technol. 2018 May 24;:
Authors: Kanduc D
Abstract
Anti-ovarian cancer vaccines based on minimal immune determinants uniquely expressed in ovarian cancer biomarkers and absent in the human proteome appear to promise a high level of sensitivity and specificity for early ovarian cancer immunodiagnostics, immunoprevention, and immunotherapy. In this context, the present study analyses three ovarian cancer biomarkers - namely sperm surface protein Sp17, WAP four-disulfide core domain protein 2, and müllerian-inhibiting substance - and describes a methodology for constructing ovarian cancer biomarker-derived oligopeptide constructs that might be useful for developing new diagnostic and immunotherapeutic approaches.
PMID: 29793409 [PubMed - as supplied by publisher]

Source: Current Drug Discovery Technologies - May 24, 2018 Category: Drugs & Pharmacology Authors: Kanduc D Tags: Curr Drug Discov Technol Source Type: research