LDL extracellular vesicle coagulation protein levels change after initiation of statin therapy. Findings from the METEOR trial

Statins are thought to have pleiotropic properties, including anticoagulant effects, in addition to reducing lipoprotein (LDL) levels. Plasma extracellular vesicles (EVs) are small bilayer membrane vesicles involved in various biological processes including coagulation. Since subsets of EVs in the LDL plasma fraction (LDL-EVs) correlate with thrombin activity, we hypothesized that changes in LDL-EVs after statin therapy may differ from that of serum levels of coagulation proteins, providing insight into the effects of statins on coagulation.

Source: International Journal of Cardiology - May 26, 2018 Category: Cardiology Authors: Laura Verbree-Willemsen, Ya-Nan Zhang, Crystel M. Gijsberts, Arjan H. Schoneveld, Jiong-Wei Wang, Carolyn S.P. Lam, Floor Vernooij, Michiel L. Bots, Linda M. Peelen, Diederick E. Grobbee, Joel S. Raichlen, Dominique P.V. de Kleijn, METEOR Study Group Source Type: research