IJERPH, Vol. 15, Pages 1077: Short-Term Particulate Air Pollution Exposure is Associated with Increased Severity of Respiratory and Quality of Life Symptoms in Patients with Fibrotic Sarcoidosis

This study aimed to determine if short-term exposure to particulate matter (PM2.5) and ozone (O3) is associated with increased symptoms or lung function decline in fibrotic sarcoidosis. Sixteen patients with fibrotic sarcoidosis complicated by frequent exacerbations completed pulmonary function testing and questionnaires every three months for one year. We compared 7-, 10-, and 14-day average levels of PM2.5 and O3 estimated at patient residences to spirometry (forced expiratory volume in 1 s (FEV1), to forced vital capacity (FVC), episodes of FEV1 decline > 10%) and questionnaire outcomes (Leicester cough questionnaire (LCQ), Saint George Respiratory Questionnaire (SGRQ), and King’s Sarcoidosis Questionnaire (KSQ)) using generalized linear mixed effect models. PM2.5 level averaged over 14 days was associated with lower KSQ general health status (score change −6.60 per interquartile range (IQR) PM2.5 increase). PM2.5 level averaged over 10 and 14 days was associated with lower KSQ lung specific health status (score change −6.93 and −6.91, respectively). PM2.5 levels were not associated with FEV1, FVC, episodes of FEV1 decline > 10%, or respiratory symptoms measured by SGRQ or LCQ. Ozone exposure was not associated with any health outcomes. In this small cohort of patients with fibrotic sarcoidosis, PM2.5 exposure was associated with increased severity of respiratory and quality of life symptoms.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research

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B Jayakrishnan, Nasser Al-Busaidi, Saif Al-Mubaihsi, Omar A Al-RawasAnnals of Thoracic Medicine 2019 14(2):106-115Sarcoidosis, a systemic granulomatous disease of unknown cause, has been described worldwide and in all populations with notable differences in clinical characteristics, organ involvement, disease severity, and prognosis among different ethnic and racial groups. While the exact prevalence of sarcoidosis in the Middle East is unknown, studies from various countries in the region have reported the clinical characteristics of affected patients, along with a few anecdotal reports. A search of the MEDLINE and Google...
Source: Annals of Thoracic Medicine - Category: Respiratory Medicine Authors: Source Type: research
Sarcoidosis is a granulomatous disease of unknown etiology that manifests as non-caseating granulomas in various organs throughout the body1 –3. Its prevalence worldwide is approximately 4.7-64 in 100,0001 and the disease has a bimodal age distribution with the first peak at 25-35 years and second peak at 45-65 years4. Sarcoid most often affects the lungs, presenting as bilateral hilar lymphadenopathy or pulmonary reticular opacities4, 5 . Pulmonary manifestations initially start as a persistent cough and can progress to worsening dyspnea1,5.
Source: Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Authors: Tags: Case Report Source Type: research
Conclusions: Cough and dyspnoea presented in primary care may be related to IPF more than five years prior to the diagnosis itself. Patients may present with cough as the first symptom as often as dyspnoea.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Idiopathic interstitial pneumonias Source Type: research
Conclusion: The surviving patients ameliorated without treatment. ATS criteria for nontuberculous mycobacterial lung disease were not met in the majority of cases. Clinical significance is uncertain. M. basiliensis seems to cause colonization or asymptomatic infection rather than disease.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tuberculosis Source Type: research
Conclusions: Elevated serum angiotensin converting enzyme (ACE) is a risk factor for recurrence in sarcoidosis patients, that may suggesting that patients with high granulomatous burden at the time of diagnose are more likely to relapse.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research
CONCLUSION: EBUS-TBNA is associated with a risk of mediastinitis that may manifest as an isolated fever arising within hours of the procedure. The pathogens responsible are usually contaminants from the oropharynx such as Streptococcus sp, probably inoculated directly into the mediastinum during transbronchial needle aspiration. Rapid diagnosis and treatment are necessary in order to reduce morbidity and mortality associated with mediastinitis. PMID: 30098879 [PubMed - as supplied by publisher]
Source: Revue des Maladies Respiratoires - Category: Respiratory Medicine Tags: Rev Mal Respir Source Type: research
CONCLUSIONS: The evidence supporting the management of chronic cough in ILD is limited. This guideline presents suggestions for managing and treating cough on the best available evidence but future research is clearly needed. PMID: 30036496 [PubMed - as supplied by publisher]
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Publication date: Available online 4 January 2018Source: Respiratory Physiology &NeurobiologyAuthor(s): Eva Kovacova, Tomas Buday, Robert Vysehradsky, Jana PlevkovaAbstractSarcoidosis is a multi-system disease of unknown aetiology characterized by presence of non-caseating granulomatous inflammation. Cough is a common and significant symptom in sarcoidosis, reducing quality of life. Objective 24 h cough monitoring proved that sarcoidosis patients have significantly higher cough frequency compared to controls and their cough has diurnal variation, it is gender-specific and shows racial differences. It correlates with ...
Source: Respiratory Physiology and Neurobiology - Category: Respiratory Medicine Source Type: research
Publication date: April–June 2018Source: Saudi Journal of Ophthalmology, Volume 32, Issue 2Author(s): Daniele Cirone, Luca Cimino, Giovanni SpinucciAbstractSarcoidosis is a multisystemic granulomatous chronic disease of unknown etiology with a wide range of clinical presentations. Diagnosis of sarcoidosis in patients with ocular manifestations can be challenging.We first describe a case of sarcoidosis presented with pulmonary involvement and both uveitis and internuclear ophthalmoplegia as ocular manifestations.A 55-year-old caucasian woman with non-productive cough and weakness presented with bilateral granulomatous...
Source: Saudi Journal of Ophthalmology - Category: Opthalmology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
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