A comparative study of sterically and electro-statically stabilized silver nanoparticles for the determination of muscle relaxant tizanidine: Insights of localized surface plasmon resonance, surface enhanced Raman spectroscopy and electrocatalytic activity.

A comparative study of sterically and electro-statically stabilized silver nanoparticles for the determination of muscle relaxant tizanidine: Insights of localized surface plasmon resonance, surface enhanced Raman spectroscopy and electrocatalytic activity. Talanta. 2018 Aug 15;186:229-237 Authors: El-Zahry MR Abstract A comparative study of two types of silver nanoparticles was investigated. The effect of the surface chemistry of the studied silver nanoparticles (AgNPs) on their localized surface plasmon resonance was utilized for the quantitative determination of muscle relaxant tizanidine drug. The studied AgNPs are classified according to the type of stabilizing agent used in their synthesis into electrostatically and sterically stabilized AgNPs. The electrostatically-stabilized AgNPs (AA AgNPs) were prepared using ascorbic acid as both reducing and protective agents in alkaline medium. The sterically-stabilized AgNPs type (PEG-AA AgNPs) was prepared using ascorbic acid as a reducing agent and polyethylene glycol as a stabilizing agent at room temperature. The interaction of tizanidine with AgNPs was characterized using four different techniques including, transmission electron microscope, UV-visible spectrophotometric, surface enhanced Raman spectroscopic (SERS) and electroanalytical methods. SERS method was developed to study the relationship between the plasmon resonance and the enhanced power of Raman signal. The electrocatal...
Source: Talanta - Category: Chemistry Authors: Tags: Talanta Source Type: research