Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles

Computations in the mammalian cortex are carried out by glutamatergic and -aminobutyric acid–releasing (GABAergic) neurons forming specialized circuits and areas. Here we asked how these neurons and areas evolved in amniotes. We built a gene expression atlas of the pallium of two reptilian species using large-scale single-cell messenger RNA sequencing. The transcriptomic signature of glutamatergic neurons in reptilian cortex suggests that mammalian neocortical layers are made of new cell types generated by diversification of ancestral gene-regulatory programs. By contrast, the diversity of reptilian cortical GABAergic neurons indicates that the interneuron classes known in mammals already existed in the common ancestor of all amniotes.
Source: ScienceNOW - Category: Science Authors: Tags: Evolution, Molecular Biology r-articles Source Type: news