Role of statins and mevalonate pathway on impaired HDAC2 activity induced by oxidative stress in human airway epithelial cells.

In conclusion, the modulation of histone acetyltransferase/deacetylase activity may lead to the development of novel anti-inflammatory approaches to inflammatory lung diseases that are currently difficult to treat.
PMID: 29782855 [PubMed - as supplied by publisher]

Source: European Journal of Pharmacology - May 18, 2018 Category: Drugs & Pharmacology Authors: Matera MG, Calzetta L, Gritti G, Gallo L, Perfetto B, Donnarumma G, Cazzola M, Rogliani P, Donniacuo M, Rinaldi B Tags: Eur J Pharmacol Source Type: research