Pharmacogenomics of drug-induced liver injury (DILI): Molecular biology to clinical applications

A number of drug-specific and host-related factors contribute to the development of drug-induced liver injury (DILI). Investigations focused on genetic susceptibility to DILI have advanced our understanding of the pathogenesis of this rare, yet potentially life-threatening adverse reaction. Candidate gene studies involving well-characterized patients with DILI and drug-exposed controls have identified single nucleotide polymorphisms (SNPs) affecting the metabolism and clearance of specific drugs and hence, influencing individual ’s susceptibility to DILI.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Grand Rounds Source Type: research