INK4a/ARF Expression Impairs Neurogenesis in the Brain of Irradiated Mice

In conclusion, our results suggest that IR-induced p16INK4a expression is a mechanism that limits neurogenesis. Teaser Palacio et al. find that ionizing radiation induces the senescence marker INK4a/ARF in neural progenitor cells and demonstrate that such expression as a mechanism leading to loss of neurogenesis. Their results suggest that treatments looking to preserve stem cell regenerative potential, by limiting INK4a/ARF expression, may help prevent radiation-related loss of neurogenesis.
Source: Stem Cell Reports - Category: Stem Cells Source Type: research