In Vitro Negative Inotropic Effect of Low Concentrations of Bupivacaine Relates to Diminished Ca 2+ Sensitivity but Not to Ca 2+ Handling or β-Adrenoceptor Signaling

Conclusions We provide evidence that the negative inotropic effect of bupivacaine may be caused mainly by a reduction in myofilament sensitivity to Ca2+.
Source: Anesthesiology - Category: Anesthesiology Source Type: research