Safety and Efficacy of Benzbromarone and Febuxostat in Hyperuricemia Patients with Chronic Kidney Disease: A Prospective Pilot Study

This study was a single-centered, parallel-grouped, randomized clinical trial (RCT). We randomly assigned hyperuricemia participants with eGFR 20 –60 mL/min/1.73 m2 into benzbromarone and febuxostat treatment group. Drugs were adjusted by titration from small doses.ResultsSeventy-three eligible participants enrolled, 66 subjects (33 in each group) were included finally for analysis. When compared to baseline, serum uric acid (SUA) decreased significantly after treatment in both groups, but no differences were detected among all the follow-up points. After 12-month treatment, eGFR did not have significant change in both groups. In the benzbromarone group, kidney stones in one case increased in quantity. In the febuxostat group, kidney stones in one case became smaller in size and in two cases vanished completely. Both drugs did not increase myocardial enzymes significantly after the treatment. In addition, hemoglobin increased significantly in the two groups (p 
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research

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Publication date: Available online 25 May 2019Source: Canadian Journal of CardiologyAuthor(s): Rebecca Rodin, Christopher T. ChanAbstractChronic kidney disease (CKD) is associated with premature cardiovascular morbidity and mortality. Traditional Framingham risk factors contribute partially to the malignant form of cardiovascular disease (CVD) in CKD. Uremic specific risk factors including: chronic inflammation, retention of uremic toxins and abnormal bone mineral metabolism have independently been linked to the pathogenesis of premature vascular aging, atherosclerosis, and CVD. This review will explore the mechanisms by w...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 24 May 2019Source: Sensors and Actuators B: ChemicalAuthor(s): Giulia Breveglieri, Elisabetta D’Aversa, Lucia Carmela Cosenza, Effrossyni Boutou, Angeliki Balassopoulou, Ersi Voskaridou, Roberto Gambari, Monica BorgattiAbstractSickle Cell Anemia (SCA) is a monogenic hereditary disease caused by a single point mutation (βS) in the β globin gene resulting in an abnormal hemoglobin (HbS) that can polymerize within the erythrocytes, inducing their characteristic sickle shape. This causes hemolytic anemia and occlusive vessels for the most severe clinical status. Molecular anal...
Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
Publication date: September 2019Source: Journal of Trace Elements in Medicine and Biology, Volume 55Author(s): Nasim Zamani, Hossein Hassanian-Moghaddam, Hooman Bahrami-Motlagh, Sara Ahmadi, Scott PhillipsAbstractObjectivesOur study attempts to determine if for patients following ingestion of lead-contaminated opium, radiographs [plain X-ray (KUB)] or unenhanced computed tomography (CT scan) of the abdomen may be predictive of lead poisoning.MethodsOur study is concerned with patients of>21 years with elevated lead concentrations, who had undergone KUB or CT. Patients with other toxicities who had undergone similar imag...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Authors: Chillo P, Ismail A, Sanyiwa A, Ruggajo P, Kamuhabwa A Abstract Background: Hypertensive retinopathy is a known marker of cardiovascular disease, and among unselected patients with chronic kidney disease (CKD) more severe retinopathy has been associated with lower estimated glomerular filtration rate (eGFR). This association has, however, not been widely studied among nondiabetic hypertensive patients with CKD, especially in sub-Saharan Africa. We aimed to determine the prevalence and severity of hypertensive retinopathy and its relationship with eGFR among nondiabetic CKD patients seen at Muhimbili Nationa...
Source: International Journal of Nephrology and Renovascular Disease - Category: Urology & Nephrology Tags: Int J Nephrol Renovasc Dis Source Type: research
ConclusionsPatients in intermediate stages do not receive follow-up with a multidisciplinary team at the recommended frequency. The preventive approach of the progression of renal disease in the intermediate stage in the studied municipality was not within the recommendations of the Ministry of Health.
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
ConclusionsThere are multiple factors associated with the increased LOS seen in patients with thermal and inhalation injury. This study confirmed and identified novel factors not previously discussed in the literature that were significantly associated with LOS. Expansion of the data submitted to the National Burn Repository and the Burn Quality Improvement Program may be warranted. This study confirms claims from previous studies on inadequacy of current data submitted for benchmarking and under-reimbursement for the care of such a complex population.
Source: Burns - Category: Dermatology Source Type: research
There are three reasons to generate a new human kidney. The first is to learn more about the biology of the developing and mature organ. The second is to generate tissues with which to model congenital and acquired kidney diseases. In particular, growing human kidneys in this manner should ultimately help to understand the mechanisms of common chronic kidney diseases such as diabetic nephropathy and others featuring fibrosis, as well as nephrotoxicity. The third is to provide functional kidney tissues that can be directly used in regenerative medicine therapies.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Review Source Type: research
Conclusion MethodologyThere were 4 clinical trials approved at the National University Malaysia in collaboration with Cytopeutics (Cyberjaya, Malaysia) which provided the mesenchymal stromal cells (Cyto-MSC) for treatment of acute stroke, heart failure, diabetes with critical limb ischemia and severe deforming osteoarthritis. All patients received 65-130 × 106 Cyto-MSC intravenously. Severity of chronic kidney disease is based on baseline estimated glomerular filtration rate (eGFR) and serum creatinine which are markers of renal dysfunction. These and other blood tests including fasting blood sugar (FBS) and Hba1...
Source: Cytotherapy - Category: Cytology Source Type: research
Condition:   Hepatitis B Vaccine Interventions:   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, and 6;   Biological: 20 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6;   Biological: 60 µg recombinant hepatitis B vaccine at months 0, 1, 2,and 6 Sponsors:   Shanxi Medical University;   Centers for Disease Control and Prevention, China Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: This case highlights the difficulties of diagnosing skin lesions caused by HCV infection in immunosuppressed patients. PMID: 31114644 [PubMed]
Source: World Journal of Hepatology - Category: Gastroenterology Tags: World J Hepatol Source Type: research
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