Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis

Hepatocellular carcinoma (HCC) is the second cause of cancer-related deaths worldwide[1]. Unfortunately, our knowledge of the genetic/epigenetic alterations implicated in HCC initiation and progression is still fragmentary and driving genetic alterations to which tumor cells are addicted and that can be targeted have not been identified. In this scenario, HCC is probably one of the tumor types where a more complete understanding of the underlying genetic alterations could have a major impact on the development of new treatment strategies.

Source: Journal of Hepatology - May 11, 2018 Category: Gastroenterology Authors: Claudia Orr ù, Marta Szydlowska, Keiko Taguchi, Patrizia Zavattari, Andrea Perra, Masayuki Yamamoto, Amedeo Columbano Source Type: research