Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD).
Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD). Cochrane Database Syst Rev. 2018 May 09;5:CD009260 Authors: Reichow B, Hume K, Barton EE, Boyd BA Abstract BACKGROUND: The rising prevalence of autism spectrum disorders (ASD) increases the need for evidence-based behavioral treatments to lessen the impact of symptoms on children's functioning. At present, there are no curative or psychopharmacological therapies to effectively treat all symptoms of the disorders. Early intensive behavioral intervention (EIBI) is a treatment based on the principles of applied behavior analysis. Delivered for multiple years at an intensity of 20 to 40 hours per week, it is one of the more well-established treatments for ASD. This is an update of a Cochrane review last published in 2012. OBJECTIVES: To systematically review the evidence for the effectiveness of EIBI in increasing functional behaviors and skills, decreasing autism severity, and improving intelligence and communication skills for young children with ASD. SEARCH METHODS: We searched CENTRAL, MEDLINE, Embase, 12 additional electronic databases and two trials registers in August 2017. We also checked references and contacted study authors to identify additional studies. SELECTION CRITERIA: Randomized control trials (RCTs), quasi-RCTs, and controlled clinical trials (CCTs) in which EIBI was compared to a no-treatment or treatment-as-usual control...
This new course of study should help fill the gap for trained professionals in Upstate New York, Upstate officials say.
Happy Saturday! This week’s Psychology Around the Net covers tech companies using persuasive design to get kids racking up more screen time, a new startup designed to help people find mental health care more quickly and affordably, how dating apps have the potential to be both helpful and hurtful, and more. Tech Companies Use ‘Persuasive Design’ to Get Us Hooked. Psychologists Say It’s Unethical: A new technique known as persuasive technology or persuasive design looks at how computers can change the way we thing and act, and big tech companies are employing mental health experts to use it — e...
Autism Research, EarlyView.
Objective: Considering the potential role of lymphocytes in the pathophysiology of autism spectrum disorder (ASD), we aimed to evaluate possible alterations of T cell pools in the lymphoid organs of an animal model of autism induced by valproic acid (VPA). Pregnant Swiss mice received a single intraperitoneal injection of 600 mg/kg of VPA (VPA group) or saline (control group) on day 11 of gestation. Male offspring were euthanized on postnatal day 60 for removal of thy muses, spleens, and a pool of inguinal, axillary and brachial lymph nodes. Cellularity was evaluated, and flow cytometry analysis was performed on cell ...
Leonardo Emberti Gialloreti, Paolo Curatolo
Miguel Á García-Cabezas, Helen Barbas, Basilis Zikopoulos
Epidiolex, a cannabis-derived medicine for epilepsy, will prompt federal regulatory changes that could crack open access to study the plant.
The level of DDT exposure to pregnant women correlates with an increased risk of autism in their children, according to a study in theAmerican Journal of Psychiatry. Medical News Today
Autism is a complex disorder with largely unknown causes.
ConclusionsWe provide pharmacological profiles of indenoisoquinoline-derived Top1 inhibitors as paternalUbe3a unsilencers. All 13 tested compounds were effective at unsilencing paternalUbe3a, although with variable efficacy and potency. Indotecan (LMP400) demonstrated a better pharmacological profile ofUbe3a unsilencing compared to our previous lead compound, topotecan. Taken together, indotecan and its structural analogues are potential AS therapeutics whose translational potential in AS treatment should be further assessed.