Activation of autophagic flux and the Nrf2/ARE signaling pathway by hydrogen sulfide protects against acrylonitrile-induced neurotoxicity in primary rat astrocytes.

In conclusion, we identified a crucial role of autophagy and the Nrf2/ARE signaling pathway in H2S-mediated neuroprotection against AN-induced toxicity in primary rat astrocytes. Our findings provide novel insights into the mechanisms of H2S-mediated neuroprotection, and suggest that H2S-based donors may serve as potential new candidate drugs to treat AN-induced neurotoxicity. PMID: 29725710 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29725710?dopt=Abstract

Source: Archives of Toxicology - May 3, 2018 Category: Toxicology Authors: Yang B, Bai Y, Yin C, Qian H, Xing G, Wang S, Li F, Bian J, Aschner M, Lu R Tags: Arch Toxicol Source Type: research