An Empirical Dietary Inflammatory Pattern Score Is Associated with Circulating Inflammatory Biomarkers in a Multi-Ethnic Population of Postmenopausal Women in the United States

AbstractBackgroundThe empirical dietary inflammatory pattern (EDIP) score has been associated with concentrations of circulating inflammatory biomarkers in European Americans.ObjectiveWe used the EDIP score, a weighted sum of 18 food groups that characterizes dietary inflammatory potential based on circulating concentrations of inflammatory biomarkers, to test the hypothesis that a pro-inflammatory dietary pattern is associated with inflammatory biomarker concentrations in a US multi-ethnic population.MethodsIn this cross-sectional study, we calculated EDIP scores using baseline food frequency questionnaire data from 31,472 women, aged 50 –79 y, in the Women's Health Initiative observational study and clinical trials. Circulating biomarkers outcomes at baseline were: C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF)-α, TNF receptor (TNFR) 1 and 2, and adiponectin. We used multivariable-adjusted linear reg ression analyses to estimate absolute concentrations and relative differences in biomarker concentrations, overall and in subgroups of race/ethnicity and BMI (body mass index) categories.ResultsIndependent of energy intake, BMI, physical activity, and other potential confounding variables, higher EDIP scores were significantly associated with higher (lower for adiponectin) absolute concentrations of all 6 biomarkers. On the relative scale, the percentage of difference in the concentration of biomarkers, among women in the highest compare...
Source: Journal of Nutrition - Category: Nutrition Source Type: research

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In this study, we sought to determine the pharmacological effects of JKW, and the mechanisms responsible, on hepatic steatosis in free fatty acids (FFAs)-stimulated HepG2 cells and in high-fat diet (HFD)-fed obese mice. Treatment with JKW significantly decreased intracellular lipid accumulation in vitro. Furthermore, JKW significantly triggered the phosphorylation of insulin receptor substrate-1 (IRS-1) and phosphoinositide 3-kinase (PI3K) and modulated glucose and lipid metabolism via an AMP-activated protein kinase (AMPK) signaling pathway. Analysis of serum parameters in HFD-fed mice showed that JKW improved glucose lev...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
ConclusionThe extracted rules after experimentation are understandable and informative to the technical and nontechnical community to predict HBP.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
ConclusionsLAERCP is a safe and successful procedure for the treatment of common bile duct lithiasis when conventional biliary access is not feasible, notably after RYGB. Larger trials still need to be performed to evaluate efficacy, technical success, and complications related to this technique.
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
AbstractBackgroundThe association between several novel adiposity indices and hyperuricemia is inconclusive. Therefore, we aimed to investigate this association so as to provide theoretical support for the management of hyperuricemia in overweight/obese individuals.MethodsA cross-sectional study was carried out among 174,698 adults. The values of body adiposity index (BAI), conicity index (CI), a body shape index (ABSI), body roundness index (BRI), visceral adiposity index (VAI), lipid accumulation product (LAP) index, and cardiometabolic index (CMI) were divided into four quartiles, and multivariate logistic analysis was ...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Conditions:   Cardiovascular Diseases;   Diabetes Mellitus;   Obesity Interventions:   Behavioral: Personal testimonial;   Behavioral: Forks Over Knives Documentary;   Behavioral: Commitment nudge;   Behavioral: Prevention nudge Sponsor:   Geisinger Clinic Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Gestational Weight Gain Intervention:   Behavioral: Lifestyle Intervention Sponsors:   Kaiser Permanente;   National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Cancer Survivor;   Obesity;   Overweight;   Prostate Adenocarcinoma;   Stage A Prostate Cancer;   Stage B Prostate Cancer;   Stage C Prostate Cancer;   Stage D Prostate Cancer;   Stage I Prostate Cancer;   Stage II Prostate Cancer;   Stage IIA Prostate Cancer;   Stage IIB Prostate Cancer;   Stage IIC Prostate Cancer;   Stage III Prostate Cancer;   Stage IIIA Prostate&n...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   PreDiabetes;   Obesity, Morbid;   Bariatric Surgery Candidate Interventions:   Other: Low carbohydrate diet;   Other: Energy-matched standard diet Sponsor:   University Hospital Inselspital, Berne Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Mental Illness Persistent;   Chronic Disease;   Hypertension;   Diabetes;   Hypercholesterolemia;   Depression;   Obesity Interventions:   Behavioral: Reverse Colocated Integrated Care;   Behavioral: Usual Care Sponsors:   Health Resources in Action, Inc.;   Methodist Healthcare Ministries of South Texas, Inc.;   Social Innovation Fund Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Diabetes;   Obesity Interventions:   Other: tDNA-MI group;   Other: tDNA-CC group;   Other: UC group Sponsor:   International Medical University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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