Protein biomarkers associated with pain mechanisms in osteoarthritis.

Protein biomarkers associated with pain mechanisms in osteoarthritis.
J Proteomics. 2018 Apr 25;:
Authors: Thudium CS, Löfvall H, Karsdal MA, Bay-Jensen AC, Bihlet AR
Abstract
Osteoarthritis (OA) is the most common arthritic disease in the world, leading to debilitating pain and destruction of joint tissues. While pain is the hallmark symptom of osteoarthritis, clear associations between pain and disease processes involved in joint deterioration are lacking. OA pain is multifactorial and may arise from multiple distinct or concurrent mechanisms, and may thus present as different pain sub-types. Several biomarkers developed to reflect important pathological processes are available, and associations between such biomarkers and OA pain may give hints to important pathological features, which have not been possible to assess using clinical, radiographic or magnetic resonance imaging techniques. This review highlights a selection of important, protein-derived biomarkers measured in body fluids from OA patients, which have been associated with different types and aspects of OA pain, and discusses the potential mechanisms behind the associations.
SIGNIFICANCE: Osteoarthritis (OA) is a heterogenous disease affecting the entire joint, including cartilage, bone and synovium. While pain is the hallmark symptom of osteoarthritis, clear associations between pain and disease processes involved in joint deterioration are lacking. Thus, the...

Source: Journal of Proteomics - April 25, 2018 Category: Biochemistry Authors: Thudium CS, Löfvall H, Karsdal MA, Bay-Jensen AC, Bihlet AR Tags: J Proteomics Source Type: research